免 疫 原：KLH conjugated synthetic peptide derived from human Polycystin 2
抗原表位：41-140/968
抗原细胞定位：Cytoplasmic
SWISS：Q13563
Gene ID ：5311
Human Gene ID：5311

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011].
Function：Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dyna
Subunit：Forms homooligomers. Isoform 1 interacts with PKD1 while isoform 3 does not. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP. Interacts with HAX1. Interacts with NEK8. Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE
Subcellular Location：Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum. Cell projection, cilium.
Tissue Specificity：Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.
DISEASE：Polycystic kidney disease 2 (PKD2) [MIM:613095]: A disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It re
Similarity：Belongs to the polycystin family.
Contains 1 EF-hand domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.