Mouse Anti-Leptin antibody |
反应物种(预测) |
Human,Mouse |
产品应用(已验证) |
IHC |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:400-800, |
研究领域 |
心血管,神经生物学,信号转导,干细胞,生长因子和激素,新陈代谢, |
标签 |
Array |
RRID:RRID
产品名称:Mouse Anti-Leptin antibody
别名: LEP; Leptin Murine Obesity Homolog; Leptin Precursor Obesity Factor; OB; Obese Protein; Obesity; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog Leptin; OBS; LEP_HUMAN.
中文名称:小鼠抗瘦素单克隆抗体
英文名称:Mouse Anti-Leptin antibody
抗体来源: Mouse
克隆类型:单克隆
细胞定位:分泌型蛋白
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原:KLH conjugated synthetic peptide derived from human Leptin
SWISS:P41159
Gene ID :3952
Human Gene ID:3952
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008].
Function:May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic
Subunit:Interacts with SIGLEC6.
Subcellular Location:Secreted (Probable).
DISEASE:Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:Belongs to the leptin family.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.