免 疫 原：KLH conjugated synthetic peptide derived from human ADAMTS1
SWISS：Q9UHI8
Gene ID ：9510
Human Gene ID：9510

ADAMTS1 is a metalloproteinase of the ADAM (A Disintegrin And Metalloproteinase) family containing disintegrin-like domains. ADAMTS1, also known as METH1, was first described as a protein elevated in invasive mouse tumors. Initial findings indicated a role for ADAMTS1 in tumor progression, since the protein was preferentially expressed in more invasive tumor cell lines. ADAMTS1 is necessary for normal growth, fertility, and organ morphology and function.
Function：Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachex
Subcellular Location：Secreted > extracellular space > extracellular matrix.
Post-translational modifications：The precursor is cleaved by a furin endopeptidase.
Similarity：Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 3 TSP type-1 domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.