免 疫 原：KLH conjugated synthetic peptide derived from human IL-7Ra
抗原表位：401-459/459
抗原细胞定位：Cytoplasmic
SWISS：P16871
Gene ID ：3575
Human Gene ID：3575

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Function：Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Subcellular Location：Secreted and Cell membrane.
Post-translational modifications：N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
DISEASE：Defects in IL7R are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterog
Similarity：Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 1 fibronectin type-III domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.