免 疫 原：KLH conjugated synthetic peptide derived from human MCT4/SLC16A3
抗原表位：401-465/465
抗原细胞定位：Cytoplasmic
SWISS：O15427
Gene ID ：9123
Human Gene ID：9123

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
Function：Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetat
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Tissue Specificity：Highly expressed in skeletal muscle.
Similarity：Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.