免 疫 原：Recombinant human CH25H protein
SWISS：O95992
Gene ID ：9023
Human Gene ID：9023

CH25H (Cholesterol 25-hydroxylase), also known as h25OH, is a 272 amino acid endoplasmic membrane protein that belongs to the sterol desaturase family. CH25H contains clusters of histidine residues essential for catalytic activity and is involved in cholesterol and lipid metabolism. CH25H catalyzes the formation of 25-hydroxycholesterol from cholesterol leading to the repression of cholesterol biosynthetic enzymes. CH25H regulates lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. CH25H utilizes diiron cofactors to catalyze the hydroxylation of hydrophobic substrates.
Function：CH25H is involved in cholesterol and lipid metabolism and catalyses the formation of 25-hydroxycholesterol from cholesterol, leading to repression of cholesterol biosynthetic enzymes. It may play an important role in regulating lipid metabolism by synthes
Subcellular Location：Endoplasmic reticulum membrane
Post-translational modifications：N-glycosylated.
Similarity：Belongs to the sterol desaturase family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.