免 疫 原：Recombinant human SPARC protein
抗原表位：18-303/303
SWISS：P09486
Gene ID ：6678
Human Gene ID：6678

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011].
Function：Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain
Subcellular Location：Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.
Similarity：Belongs to the SPARC family.
Contains 1 EF-hand domain.
Contains 1 follistatin-like domain.
Contains 1 Kazal-like domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.