Rabbit Anti-THRB antibody |
产品应用(已验证) |
IHC,FCM |
产品应用(可尝试) |
ELISA |
推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:200-800,Flow Cyt=1ug/Test, |
研究领域 |
心血管,细胞生物,神经生物学,生长因子和激素,内分泌病, |
标签 |
Array |
RRID:RRID
产品名称:Rabbit Anti-THRB antibody
别名: Thyroid Hormone Receptor beta; Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2; C ERBA 2; C ERBA BETA; c-erbA-2; c-erbA-beta; ERBA 2; ERBA BETA; ERBA2; Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian; generalized resistan
中文名称:甲状腺激素受体β抗体
英文名称:Rabbit Anti-THRB antibody
抗体来源: Rabbit
克隆类型:多克隆
细胞定位:细胞核
性 状:Liquid
亚 型:IgG
纯化方法:affinity purified by Protein A
免 疫 原:Recombinant human THRB protein
抗原表位:209-461/461
SWISS:P10828
Gene ID :7068
Human Gene ID:7068
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptor b2 (TRb2) is a high affinity receptor for triiodothyronine which belongs to the nuclear hormone receptor family and the NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Defects in the receptor result in generalized thyroid hormone resistance (GTHR). GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone.
Function:Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.