免 疫 原：KLH conjugated synthetic peptide derived from human E-cadherin
抗原表位：401-500/882
抗原细胞定位：Extracellular
SWISS：P12830
Gene ID ：999
Human Gene ID：999

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Function：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regul
Subunit：Homodimer.
Subcellular Location：Cell junction. Cell membrane; Single-pass type I membrane protein.
Tissue Specificity：Non-neural epithelial tissues.
Post-translational modifications：Defects in CDH1 are the cause of hereditary diffuse gastric cancer (HDGC) . An autosomal dominant cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly
Similarity：Contains 5 cadherin domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.