免 疫 原：KLH conjugated synthetic peptide derived from human GLUT2
抗原表位：431-524/524
抗原细胞定位：Cytoplasmic
SWISS：P11168
Gene ID ：6514
Human Gene ID：6514

Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008].
Function：Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism o
Subcellular Location：Membrane; Multi-pass membrane protein.
Tissue Specificity：Liver, insulin-producing beta cell, small intestine and kidney.
Post-translational modifications：N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
DISEASE：Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS) [MIM:227810]. FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction
Similarity：Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.