免 疫 原：KLH conjugated synthetic peptide derived from human CEA/CD66e/CEACAM5
抗原表位：301-400/702
SWISS：P06731
Gene ID ：1048
Human Gene ID：1048

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Function：Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
Subunit：Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Subcellular Location：Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity：Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Post-translational modifications：Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Similarity：Belongs to the immunoglobulin superfamily. CEA family.
Contains 7 Ig-like (immunoglobulin-like) domains.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.