免 疫 原：KLH conjugated synthetic peptide derived from human NOX2
抗原表位：501-570/570
抗原细胞定位：Cytoplasmic
SWISS：P04839
Gene ID ：1536
Human Gene ID：1536

NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.
Function：Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exte
Subcellular Location：Membrane.
Post-translational modifications：Glycosylated.
DISEASE：Defects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have i
Similarity：Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.