免 疫 原：KLH conjugated synthetic peptide derived from mouse MyoD1
抗原表位：51-150/318
SWISS：P10085
Gene ID ：17927
Human Gene ID：4654

This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
Function：Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of b
Subunit：Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5.
Subcellular Location：Nucleus.
Post-translational modifications：Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its
Similarity：Contains 1 bHLH (basic helix-loop-helix) domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.