免 疫 原：KLH conjugated synthetic peptide derived from human neuropilin-1
抗原表位：851-923/923
抗原细胞定位：Cytoplasmic
SWISS：O14786
Gene ID ：8829
Human Gene ID：8829

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Function：The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of
Subunit：Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1.
Subcellular Location：Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue Specificity：The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and
Similarity：Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.