免 疫 原：KLH conjugated synthetic peptide derived from human CRHR2
抗原表位：51-150/411
抗原细胞定位：Extracellular
SWISS：Q13324
Gene ID ：1395
Human Gene ID：1395

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Function：This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subunit：Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Similarity：Belongs to the G-protein coupled receptor 2 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.