免 疫 原：KLH conjugated synthetic peptide derived from human CD36L1
抗原表位：21-100/552
抗原细胞定位：Extracellular
SWISS：Q8WTV0
Gene ID ：949
Human Gene ID：949

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI (Scavenger Receptor BI) protein binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.
Function：Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free an
Subunit：Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1.
Subcellular Location：Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Tissue Specificity：Widely expressed.
Post-translational modifications：N-glycosylated.
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
Similarity：Belongs to the CD36 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.