| Rabbit Anti-PAR4 antibody |
| 反应物种（预测） |
Mouse,Dog,Pig,Cow,Horse,GuineaPig |
| 产品应用（可尝试） |
IHC,IF,ELISA |
| 推荐稀释比例 |
Elisa=1:5000-10000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
| 研究领域 |
细胞生物,信号转导,激酶和磷酸酶,细胞膜受体 |
| 标签 |
Array |
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Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-PAR4 Polyclonal Antibody, Unconjugated(bs-1196R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
RRID：AB_10856799
产品名称：Rabbit Anti-PAR4 antibody
别名： F2RL3;
F2R Like Thrombin/Trypsin Receptor 3;
Coagulation Factor II (Thrombin) Receptor-Like 3;
Thrombin Receptor-Like 3;
PAR-4;
Coagulation Factor II Receptor-Like 3;
Proteinase-Activated Receptor-4;
Proteinase-Activated Receptor 4;
Protease-Activ
中文名称：蛋白酶活化受体4抗体
英文名称：Rabbit Anti-PAR4 antibody
抗体来源： Rabbit
克隆类型：多克隆
细胞定位：细胞膜
性 状：Liquid
亚 型：IgG
纯化方法：affinity purified by Protein A
保存条件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
免 疫 原：KLH conjugated synthetic peptide derived from human Proteinase-activated receptor 4
抗原表位：301-385/385
SWISS：Q96RI0
Gene ID ：9002
Human Gene ID：9002
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008]
Function：Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Tissue Specificity：Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
Post-translational modifications：A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Similarity：Belongs to the G-protein coupled receptor 1 family.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
400-901-9800
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