免 疫 原：KLH conjugated synthetic peptide derived from human BDP/ARID3B
抗原表位：251-350/561
SWISS：Q8IVW6
Gene ID ：10620
Human Gene ID：10620

ARID3B represents a member of a unique family of DNA-binding proteins that have roles in cell lineage gene regulation, cell cycle control, embryonic patterning and transcriptional regulation. ARID3B localizes to the nucleus and contains an AT-rich interactive domain (ARID) which has DNA-binding capabilities. Functioning as a transcription factor, ARID3B associates in a heterodimer with the related protein ARID3A and is believed to play an important role in neural crest survival during embryogenesis. In addition, ARID3B may participate in malignant transformation and neuroblastoma growth, suggesting a possible use of ARID3B as a tumor marker for neuroblastoma.
Function：Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.
Subunit：Heterodimer with ARID3A. Interacts with unphosphorylated RB1.
Subcellular Location：Nucleus.
Tissue Specificity：Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K562 erythrocytic leukemia cells (at protein level).
Similarity：Contains 1 ARID domain.
Contains 1 REKLES domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.