免 疫 原：Recombinant human ADAM17 protein
抗原表位：700-824/824
抗原细胞定位：Cytoplasmic
SWISS：P78536
Gene ID ：6868
Human Gene ID：6868

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].
Subunit：Interacts with MAD2L1, MAPK14 and MUC1.
Subcellular Location：Membrane.
Tissue Specificity：Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Similarity：Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.