免 疫 原：Prostate Specific Antigen (PSA) Antigen, Native
SWISS：P07288
Gene ID ：354
Human Gene ID：354

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function：Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Subunit：Forms heterodimer with SERPINA5.
Subcellular Location：Secreted.
Tissue Specificity：Prostate.
Similarity：Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
Important Note：This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.